Taming the Forces that Drive Cancer

Genetic Alterations Expose Tumor Vulnerabilities

Our precision molecules hit tumors at their Achilles heel.

Molecular Machines Drive Tumor Evolution

A majority of cancers can be targeted by disrupting the machines that are vital to the dynamic reorganization of the tumor genome.

Hitting the Achilles Heel of our Targets

Eisbach’s discovery engine exploits the unique key that ignites the activity of each of our targets, generating new classes of allosteric drugs.

A Bold Vision for Precision Medicine

By pioneering drugs which selectively tame the machines that disrupt genome reorganization, we stop tumor growth and enable new cancer therapies.

Our Science

We develop smart drugs targeting the machines that remodel the genome

Tumor genomes reveal that molecular machines which reorganize chromatin and genome structure have critical and typically very specific roles in the development of a majority of human cancers.

We target two classes of molecular machines vital for genome reorganisation

Eisbach develops selective drugs targeting nucleosome remodeling enzymes and DNA-dependent nuclear helicases. Chromatin remodellers turn genes on/off or promote DNA repair by changing the way that the tumor DNA is packaged within the cancer cell. Other nuclear helicases are absolutely critical for many DNA repair pathways critical to tumor cell evolution and survival.

DNA damage activates PARPs, which unleashes a machine that is key to genome reorganization

DNA damage in cancer cells leads to the activation of PARP1 and PARP2 enzymes. This generates an allosteric signal that is key to the recruitment of the nucleosome remodeling enzyme ALC1. Upon recognizing this signal, the ALC1 machine powers the repair of damaged DNA by reorganizing chromatin structure and modulating the DNA retention of PARPs and other DNA repair enzymes. DNA damage is thus efficiently repaired when ALC1 is active. Disrupting ALC1 activity in cancer cells suppresses DNA damage repair pathways vital to cancer cells and robustly potentiates the efficacy of chemotherapies and PARP inhibitors.

Our Approach

We are a pioneering precision oncology company focused on genome reorganization

Eisbach enables the potential of synthetic lethality by exploiting the unique molecular vulnerabilities present in validated cancer targets. Our ALLOS platform systematically recapitulates the tight controls that strictly regulate the activity of our cancer-driving molecular machines. We exploit this regulation to develop targeted allosteric therapies for chromatin reorganization.

Our privately-held company was founded in 2019 by academic and drug discovery pioneers in order to enable the full potential of synthetic lethality.

We strive for game-changing and safe synthetic-lethal therapies

Now is the time to leverage the power of tumor genomics to develop the right drugs for the right patients. We now know that tumors harbor genetic fingerprints that reveal specific, targetable vulnerabilities. This concept, known as synthetic lethality, allows us to target specific proteins that are essential for the survival of cancer cells, but not normal cells. By targeting these Achilles heels, the cancer cells are unable to repair their genome and die, while non-tumor cells are spared.

A leading example of synthetic lethality in cancer therapy involves PARP inhibitors, which impact related DNA repair pathways to those we target. While powerful and effective, this approach can be challenged by dose-limiting toxicities and the development of resistance to PARP inhibitors.

Enabling synthetic-lethality by targeting molecular vulnerabilities

Eisbach combines synthetic lethality with a disruptive, orthogonal approach to drug discovery, our proprietary ALLOS platform. We focus on the molecular machines essential to the dynamic reorganization of the cancer genome. Next, we discover the unique key that is required to ignite the power of each of our machines. This allows us to systematically develop allosteric drugs that disrupt these vital molecular controls.

Our groundbreaking discovery engine ALLOS crafts drugs that are effective, selective and show fewer side effects compared to traditional approaches. We turn the promise of synthetic lethality into reality by developing first-in-class therapies, by enabling powerful combination treatments and by suppressing resistance mechanisms toward targeted cancer therapies.

Our Pipeline

Our small molecule candidates inhibit the activation of cancer-promoting molecular machines.

Eisbach’s pipeline of allosteric drugs targeting chromatin reorganization has the potential to enable the fourth wave of therapeutics in oncology.

Target 1: ALC1

Enabling novel synthetic-lethal relationships in HRD tumors that suppress PARPi resistance

Target selection

ALC1 (amplified in liver cancer 1; also known as CHD1L, chromodomain helicase DNA-binding protein 1-like) is a chromatin remodeling enzyme that modulates DNA damage and repair. Its expression is increased in breast and ovarian cancers marked by deficiencies in homologous recombination (HRD-positive). Its absence robustly potentiates the efficacy of PARP inhibitors and a wide range of standard-of-care chemotherapies. ALC1 inhibitors are expected to induce synthetic lethality in HR-deficient tumors, to potentiate PARP inhibitors in patients who develop PARPi resistance and to enable potent combination therapies. Available diagnostic approaches enable the selection of patients in the clinic.

Selectivity by design

Selective inhibitors for ALC1 have to potential to exhibit a wide therapeutic window, since the ALC1 gene is not essential for life, but rather plays a targeted role in situations of high DNA damage, as can be present in cancer or when a patient’s tumor is treated with DNA damage agents or radiation therapy. The critical dependence of ALC1 activity on its unique allosteric key (known as poly-ADP-ribose) allowed us to screen for and develop selective drugs with a superior safety and tolerability profile compared to existing therapies.

Target 2: CHD1

Allosteric inhibition for beneficial immunomodulation in synthetic-lethal PTEN-deficient cancer

Target selection

CHD1 (chromodomain helicase DNA-binding protein 1) is a chromatin remodeller that regulates gene expression, plays a role in DNA repair and modulates the immune system to impact the tumor microenvironment. Its absence disables the ability of cancer cells deficient in the PTEN tumor suppressor to grow. Genetic deletion of CHD1 reduces metastases in animals models of prostate cancer. CHD1 inhibitors are expected to induce synthetic lethality in PTEN-deficient tumors, enabling novel immunomodulatory approaches in oncology.

Nuclear helicases

Allosteric targeting of validated, synthetic lethal molecular machines

Target selection

A wide range of additional, DNA-dependent nuclear enzymes and molecular machines contain helicase engines that are essential in highly specific, genetic tumor contexts, while being dispensable in non-cancer cells. These synthetic lethal vulnerabilities represent a promising avenue toward the development of novel, targeted therapies in defined cancer populations.

Our Team

celia

Celia Schell

Clinical Operations

bill

William Menzer

Medicinal Chemistry & CMC

markus

Markus Lechner

Preclinical

dana

Dana Matzek

Animal Models

xin

Xin Zhang

Cancer Biology

lucas

Lucas Kalczynski

Preclinical

charlotte

Charlotte Rammoser

Cancer Biology

peter

Peter Sennhenn

Medicinal Chemistry

john

Jonathan Iorio

Director of Finance

drdd

Deepak

Biochemistry

andreas

Andreas Ladurner

Science

adrian

Adrian Schomburg

Operations

gunnar

Gunnar Knobloch

Biochemistry

jörk

Jörk Zwicker

IP

margit

Margit Schmidt

Clinical Operations

daniel

Daniel Gau

Business Development

Nadine Ntaraklitas

Animal Models

Junmei Liu

Cancer Biology

Join us

We are a bold, curious and relentless team.

We will transform the lives of cancer patients by delivering on the promise of synthetic lethality through allosteric drugs.

Open Positions:

We are looking for a Clinical Operations Manager (d/f/m, Munich, Full Time)

Eisbach is a cutting-edge biotechnology company based in Munich, focused on the discovery and development of transformative drugs in the fields of oncology and infectious diseases. Leveraging our unique insights into the activation mechanisms of targeted molecular machines, we’re committed to creating effective and safe medical solutions.

Position Overview

We are currently looking for a dedicated Clinical Operations Manager to join our dynamic team. In this pivotal role, you will be responsible for the planning, coordination, and oversight of our clinical trials. You will work closely with the VP of Clinical Development and other key stakeholders to ensure that studies are completed on time, within budget, and in compliance with regulatory standards.

About you

Project Management: Proven experience in managing clinical trials, ideally in the fields of oncology or infectious diseases. We require strong organizational and multitasking abilities.

Academic & Professional Background: A Bachelor’s or Master’s degree in a life science subject, nursing, or related field is required. Certification in Clinical Research Professional (CCRP) or equivalent is preferred.

Regulatory Compliance: Thorough understanding or keen to learn clinical trial regulations, GCP guidelines, and ethical standards and considerations.

Collaboration & Communication: Exceptional interpersonal skills, capable of collaborating effectively with cross-functional teams, external partners, and regulatory bodies. Fluency in English, both written and spoken, is a must.

Analytical Skills: Detail-oriented and data-driven, with a strong ability to analyze trial data, identify trends, negotiate and implement corrective actions as needed.

Adaptability: Thrives in a fast-paced environment, adaptable to change, and capable of handling complex situations with a hands-on mentality. Comfortable navigating the evolving landscape of drug development and regulatory requirements. Able to recognize opportunities, respond to challenges, adapt to evolving priorities, and excelling in a fast-paced team setting for the benefit of our patients.

Team Dynamics: A team player who can effectively interface with internal teams, external partners, and stakeholders. Builds on our international team by cultivating a culture of excellence, inclusion, and diversity within the work environment and beyond.

 

We offer a competitive salary, comprehensive benefits and a Stock Option Plan that allows you to share in the long-term success and growth of our company Eisbach.

If you are a driven, committed, and inventive professional looking to make a significant impact for our patients, we love to hear from you.

To apply, please submit your CV and an informative cover letter detailing your experience and suitability.

We deliver on the promise of our cutting-edge science to pioneer new drugs. Together, we pledge to transform the lives of patients and be stewards of our community.

How will you apply your curiosity? Tell us at: careers@eisbach.bio

We are looking for a Clinical Study Coordinator (d/f/m, Munich, full Time)

Eisbach is a cutting-edge biotechnology company based in Munich, focused on the discovery and development of transformative drugs in the fields of oncology and infectious diseases. Leveraging our unique insights into the activation mechanisms of targeted molecular machines, we’re committed to creating effective and safe medical solutions.

Position Overview

We are looking for a dedicated Clinical Study Coordinator to join our dynamic team. In this pivotal role, you will be responsible for supporting the Project Lead in the operational execution and oversight of a clinical Ph1/2 study, ensuring the completion of all study deliverables. You will assist in providing oversight of the vendors and work closely with all study team members under the responsibility of the Project Lead. At least 2 years of clinical study experience are required.

Responsibilities

Assist in all operational activities of the clinical study, such as:

·Coordinate development and approval of study documentation
·Develop and maintain tools to follow study timelines, milestones and budget
·Coordinate forecasting and availability of IMP and study materials
·Coordinate collection of study samples and ensure analysis conducted as planned
·Lead relevant meetings (internal and external) to follow study deliverables
·Implement appropriate quality control of all deliverables, internal or from the service providers
·Follow monitoring activities and review monitoring reports
·Follow study quality with regular check of reports produced, including study deviations, follow-up of SAEs, and queries
·Ensure proper study documentation is maintained and archived in the TMF
·Assist in study budget management and control, including review of  invoices
·Support with SOP tracking and training of team members
·Assist in the development of relevant clinical SOPs

 

We offer a competitive salary, comprehensive benefits and a Virtual Stock Option Plan that allows you to share in the long-term success and growth of our company Eisbach.

If you are a driven, committed, and inventive professional looking to make a significant impact for our patients, we love to hear from you.

To apply, please submit your CV and an informative cover letter detailing your experience and suitability.

We deliver on the promise of our cutting-edge science to pioneer new drugs. Together, we pledge to transform the lives of patients and be stewards of our community.

How will you apply your curiosity? Tell us at: careers@eisbach.bio

We are looking for a Quality Manager (d/f/m, Munich, Part Time)

Eisbach is a cutting-edge biotechnology company based in Munich, focused on the discovery and development of transformative drugs in the fields of oncology and infectious diseases. Leveraging our unique insights into the activation mechanisms of targeted molecular machines, we’re committed to creating effective and safe medical solutions.

Position Overview

We are seeking a Quality Manager who can play a pivotal role in overseeing the quality assurance and quality control activities related to our clinical trials while ensuring compliance with GxP regulations. The person will be responsible for maintaining a robust quality management system and ensuring that all aspects of our clinical trials adhere to regulatory guidelines and industry best practices. Moreover, the Quality Manager will be responsible for training of staff to ensure compliance with industry standards and Eisbach’sSOPs and QC policies.

About you

Key skills: You can demonstrate ability to develop, implement, and maintain an effective QMS tailored to the specific needs of our company and our clinical research, with a strong focus on GxP regulations.

Experience: You have knowledge or keen to learn relevant GxP regulations and guidelines and experience with preparing and submitting necessary documentation for regulatory approvals and inspections. You can identify potential quality and compliance risks associated with clinical trials and develop mitigation strategies.

Audit: You can plan and conduct internal audits to assess compliance with quality standards and GxP regulations. You have experience in collaborating with external auditors and regulatory agencies during inspections and audits.

Academic & Professional Background: An advanced degree in a relevant discipline is preferred, along with extensive experience in clinical development/quality management.

Communication Skills: Strong leadership and communication skills, with the ability to collaborate effectively with cross-functional teams.

 

We offer a competitive salary, comprehensive benefits and a Stock Option Plan that allows you to share in the long-term success and growth of our company Eisbach.

If you are a driven, committed, and inventive professional looking to make a significant impact for our patients, we love to hear from you.

To apply, please submit your CV and an informative cover letter detailing your experience and suitability.

We deliver on the promise of our cutting-edge science to pioneer new drugs. Together, we pledge to transform the lives of patients and be stewards of our community.

How will you apply your curiosity? Tell us at: careers@eisbach.bio

We are looking for a CMC Specialist (d/f/m, Munich, Full Time)

Eisbach is a cutting-edge biotechnology company based in Munich, focused on the discovery and development of transformative drugs in the fields of oncology and infectious diseases. Leveraging our unique insights into the activation mechanisms of targeted molecular machines, we’re committed to creating effective and safe medical solutions.

Position Overview

We are in search of an exceptional Chemistry, Manufacturing, and Control (CMC) Specialist to join our team and take a lead role in our organization. As a CMC Specialist, you will play a critical role in shaping our CMC strategies, overseeing the manufacturing processes, and ensuring the quality control of our drug candidates in oncology. Your expertise in CMC and strategic leadership will be pivotal in translating innovative laboratory results into ground-breaking new therapies.

About you

CMC Strategy: Develop and implement CMC strategies to ensure the successful development and manufacturing of our drug candidates. Support the planning and execution of CMC activities to meet all regulatory requirements.

Qualifications and Experience: An advanced degree in a relevant discipline is preferred. Extensive experience in CMC, with a strong background in clinical development, particularly in oncology.

Strategic Thinking: Possess the ability to shape and articulate a clear strategic vision for CMC. Make informed decisions based on comprehensive risk assessment and forward planning.

Industry Experience: Ideally relevant experience in the pharmaceutical or biotechnology industry, with a focus on CMC in clinical development.

Communication Skills: Exceptional ability to communicate complex CMC concepts clearly and effectively, both in written and verbal formats. Proficiency in English is required, and knowledge of other languages is a plus.

Team Collaboration: Be a collaborative leader who can effectively work with internal teams and external partners. Foster a culture of excellence, inclusion, and diversity within the workplace and beyond.

Adaptability: Comfortable navigating the evolving landscape of CMC development and regulatory requirements. Recognize opportunities, address challenges, and adapt to changing priorities in a fast-paced team setting for the benefit of our patients.

 

We offer a competitive salary, comprehensive benefits and a Stock Option Plan that allows you to share in the long-term success and growth of our company Eisbach.

If you are a driven, committed, and inventive professional looking to make a significant impact for our patients, we love to hear from you.

To apply, please submit your CV and an informative cover letter detailing your experience and suitability.

We deliver on the promise of our cutting-edge science to pioneer new drugs. Together, we pledge to transform the lives of patients and be stewards of our community.

How will you apply your curiosity? Tell us at: careers@eisbach.bio

We are looking for a Executive Assistant (d/f/m, Munich, Full Time)

 

Eisbach is a cutting-edge biotechnology company based in Munich, focused on the discovery and development of transformative drugs in the fields of oncology and infectious diseases. Leveraging our unique insights into the activation mechanisms of targeted molecular machines, we’re committed to creating effective and safe medical solutions.

Position Overview

We are seeking a highly organized, confident, dynamic and solution-driven Executive Assistant to provide transformatively support our Managing Directors. Join our Eisbach Bio GmbH team and play a crucial role in supporting leadership and ensuring Eisbach’sefficient operation.

About you

Administrative Support: Manage and maintain the schedules, appointments, and travel arrangements for the Managing Directors. Handle correspondence and maintain records and files.

Meeting Coordination: Arrange and coordinate meetings, conferences, and events. Prepare meeting materials, take minutes, follow up on action items and help the team to deliver on schedule and to high standards.

Communication: Serve as a primary point of contact between the Managing Directors and internal/external stakeholders. Professionally handle all inquiries and requests in a timely and effective manner. Ideally, the candidate should be fluent in both English and German.

Office Management: Ensure a well-organized and efficient environment.

Proven Experience: Experience as an Executive Assistant or similar role is preferred, but not mandatory. Demonstrated ability to handle a wide range of administrative tasks and support strategic and scientific goals.

Communication Skills: Excellent written and verbal communication skills. Ability to interact professionally with individuals at all levels.

Organizational Skills: Strong organizational and time-management skills. Adept at multitasking and prioritizing tasks. Inventive about finding practical solutions with minimal effort and resource consumption.

Tech-Savvy: Proficiency in MS Office (Word, Excel, PowerPoint) and other relevant teamwork software. Familiarity with office equipment, ability to apply new technologies, have a good eye for spotting typos and any other inconsistency in presentations and communication.

Adaptability: Ability to thrive in a fast-paced environment and handle changing priorities with a reliably highly positive attitude.

Discretion: Maintain full confidentiality of sensitive information and use good judgment in all aspects of the leadership support role.

 

We offer a competitive salary, comprehensive benefits and a Stock Option Plan that allows you to share in the long-term success and growth of our company Eisbach.

If you are a driven, committed, and inventive professional looking to make a significant impact for our patients, we love to hear from you.

To apply, please submit your CV and an informative cover letter detailing your experience and suitability.

We deliver on the promise of our cutting-edge science to pioneer new drugs. Together, we pledge to transform the lives of patients and be stewards of our community.

How will you apply your curiosity? Tell us at: careers@eisbach.bio

News

MARTINSRIED, Germany, May 24, 2024 – Eisbach Bio GmbH (“Eisbach” or the “Company”), a privately-held clinical-stage biotechnology company pioneering cancer medicines leveraging synthetic lethality, has announced completion and Phase I topline results of EIS-10700. The safety, tolerability and pharmacokinetics of EIS-10700 were investigated in a first-in-human, open label, single center, single dose escalation Phase I study in Germany.

Due to the excellent safety profile obtained in GLP toxicology studies (i.e. MTD in dogs >500 mg/kg), the first cohort of trial participants were given a starting daily dose of 500 mg. The Phase I study enrolled a total of 33 patients in five groups, using escalating dose levels of EIS-10700 in fasted and fed conditions. Subjects received up to the maximum dose of 3.000 mg without a single report of dose limiting toxicity associated with the investigational agent, confirming prior preclinical findings. EIS-10700 demonstrated dose dependent plasma exposure.

“We are excited to complete our first clinical study, which demonstrated the excellent tolerability and PK of EIS-10700.” said Adrian Schomburg, CEO of Eisbach. “Based on the achieved plasma levels, we are excited to now proceed with investigating the anti-tumor efficacy of this first-in-class helicase inhibitor.”

“These results represent another milestone for our proprietary AI-supported ALLOS drug discovery engine. EIS-10700 showed that it is possible to develop safe first-in-class drug candidates targeting helicases.” said Prof. Andreas Ladurner, Founder and CSO of Eisbach. “By integrating structural biology, AI and chemistry, we can target the molecular transitions in machines that are required to reorganize nucleic acids, allowing us to power a differentiated pipeline of safe drugs on novel targets.”

About the EIS-10700 Phase 1 Clinical Trial

First-in-human, open label, single center, single and multiple dose escalation Phase I study in heathy subjects of EIS-10700 conducted in Germany. EIS-10700 is a novel small molecule helicase inhibitor. EIS-10700 is the first clinical program derived from Eisbach’s ALLOS drug discovery engine.

About Eisbach

Eisbach is at the forefront of precision oncology, developing allosteric drugs that selectively disrupt molecular machines vital for tumor genome reorganization. By combining genetic vulnerabilities with its proprietary ALLOS platform, which hits the molecular vulnerability of its cancer targets, Eisbach pioneers first-in-class therapies with fewer side effects. For more information, visit https://www.eisbach.bio/ and follow us on LinkedIn.

 

Contacts

Eisbach Bio GmbH

Corporate:

Adrian Schomburg, CEO

info@eisbach.bio

 

Media:

Jonathan Iorio

+49 89 2153 79013

mediarelations@eisbach.bio

MARTINSRIED, Germany, May 6, 2024 – Eisbach Bio GmbH (“Eisbach” or the “Company”), a privately-held clinical-stage biotechnology company pioneering cancer medicines leveraging synthetic lethality, has announced United States Food and Drug Administration (FDA) clearance of its investigational new drug (IND) application for EIS-12656, a small molecule inhibiting the chromatin helicase ALC1 (CHD1L). EIS-12656 targets ALC1 through allosteric mechanisms, suppressing the cancer-relevant genome reorganization induced by DNA damage. This leads to ALC1 chromatin trapping and cancer cell killing.

EIS-12656 impacts tumors deficient in DNA repair pathways. It demonstrated substantial tumor growth inhibition in preclinical models, including in combination with standard-of-care therapies. Its allosteric mechanism of action should afford selectivity compared to related synthetic lethal targets, contributing to the exceptional safety observed in all relevant preclinical models.

“EIS-12656 selectively targets tumors with no apparent effects on normal tissues.” said Adrian Schomburg, Ph.D., Founder and CEO of Eisbach. “Our clinical study will also explore combination therapies that were hindered by combinatorial toxicity in the past.”

The discovery of EIS-12656 builds on the pioneering research of Eisbach founder Prof. Andreas Ladurner, whose team discovered that PARP effects in cancer cells are reliant on chromatin remodeling by ALC1. Eisbach built upon this knowledge and designed a first-in-class, once-daily small molecule therapy, directly targeting cancer genome reorganization induced by DNA damage at its source – the PARP-activated helicase ALC1.

About the Phase 1/2 Clinical Trial

The open label study of EIS-12656 will evaluate its safety, tolerability and efficacy in patients with genetically-defined advanced solid tumors. Led by Principal Investigator Timothy A. Yap, M.B.B.S., Ph.D., Professor of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center, the trial includes dose escalation of EIS-12656 monotherapy, followed by dose expansion modules and evaluation in patients progressing under PARP inhibitor treatment.

About Eisbach

Eisbach is at the forefront of precision oncology, developing allosteric drugs that selectively disrupt molecular machines vital for tumor genome reorganization. Combining genetic vulnerabilities with its proprietary ALLOS platform, which hits the molecular vulnerability of its cancer targets, Eisbach pioneers first-in-class therapies with fewer side effects. For more information, visit https://www.eisbach.bio/ and follow us on LinkedIn.

 

Contacts

Eisbach Bio GmbH

Corporate:

Adrian Schomburg, CEO

info@eisbach.bio

 

Media:

Jonathan Iorio

+49 89 2153 79013

mediarelations@eisbach.bio

MARTINSRIED, Germany and HOUSTON, Texas, March 21, 2024 – Eisbach Bio GmbH (Eisbach), a clinical-stage biotechnology company pioneering a new class of cancer medicines leveraging synthetic lethality to target specific proteins that are essential for the survival of cancer cells, and Cancer Focus Fund, LP, a unique investment fund established in collaboration with The University of Texas MD Anderson Cancer Center (MD Anderson) to provide funding and clinical expertise to advance promising cancer therapies, today announced that Cancer Focus Fund is investing $4.5 million to support a Phase 1/2 clinical trial of Eisbach’s lead candidate, EIS-12656, which will be conducted at MD Anderson.

EIS-12656 is a small molecule designed to treat tumors that are refractory or resistant to PARP inhibitors. PARP enzymes are involved in critical DNA repair processes. By hindering DNA repair, PARP inhibitors cause tumor cell death, and they have been effective therapies for many ovarian, breast, prostate, and pancreatic cancers. However, their use has been limited by serious toxicities and the development of resistance. EIS-12656 inhibits the chromatin remodeling enzyme ALC1, which is critical to the DNA repair process associated with PARP activation. EIS-12656 was developed by Eisbach to disrupt DNA-damage-dependent PARP activation at an early stage of the repair process. In preclinical studies EIS-12656 overcame PARP inhibitor resistance and demonstrated a benign toxicity profile and blood-brain-barrier penetrance, as well as synergy with PARP inhibitors and other standard-of-care therapies.

“Overcoming the widespread resistance and debilitating side-effects of PARP inhibitors required us to re-think how we tackle the genetic vulnerabilities prevalent in these tumors,” said Dr. Adrian Schomburg, Founder and CEO of Eisbach. “EIS-12656 is a first-in-class small molecule that targets and shuts down the molecular process that reorganizes the tumor genome upon DNA damage and PARP activation – a process that is essential to the survival of cancer cells. Based on its exceptional safety profile and promising activity in preclinical studies, we believe that EIS-12656 has the potential to benefit the many patients with tumors refractory to PARP inhibitors –patients who have few treatment options available today.”

Dr. Andreas Ladurner, Founder and CSO of Eisbach, and Professor and Chair of Physiological Chemistry at Ludwig-Maximilians-University of Munich, commented, “Most cancers contain genome reorganization mechanisms that play critical and very specific roles in tumor biology. By identifying how each of these vital mechanisms is selectively regulated, we can exploit unique molecular vulnerabilities. This approach holds great promise for the discovery of new cancer drugs that are both selective and safe.”

“Eisbach’s distinctive and scientifically sophisticated approach to addressing common difficult-to-treat cancers aligns perfectly with our goals at Cancer Focus Fund,” said Ross Barrett, a founder and Managing Partner of Cancer Focus Fund. “We aim to help innovative young companies like Eisbach to rapidly advance unusually promising new cancer drugs into clinical trials with the help of the expert researchers and clinicians at MD Anderson. EIS-12656 has demonstrated the potential to treat many relapsed and refractory tumors more effectively and with fewer side effects than current therapies, and we look forward to following the progress of this exciting first-in-class compound as it proceeds in clinical development. We also are delighted to expand our geographic reach with this first investment in a biotech company based in Germany, with its rich history of biomedical innovation.”

Timothy A. Yap, M.B.B.S., Ph.D., Professor of Investigational Cancer Therapeutics and Vice President and Head of Clinical Development in the Therapeutics Discovery division at MD Anderson, will serve as Principal Investigator of the trial.

 

About the EIS-12656 Phase 1/2 Clinical Trial

The Phase 1/2 open label study will assess the safety, tolerability, and efficacy of EIS-12656 as solo therapy in patients with various solid tumors. The study will involve dose escalation of EIS-12656 monotherapy to establish safety and determine the maximum tolerated dose and recommended Phase 2 dose. In the following stage, dose expansion modules will be conducted with EIS-12656 monotherapy. Additional modules will involve patients progressing under PARP inhibitor treatment.

 

About EIS-12656, a small molecule inhibitor of ALC1 (CHD1L)

EIS-12656, the lead oncology program at Eisbach, is a first-in-class allosteric small molecule inhibitor targeting the PARP-activated chromatin remodeling helicase ALC1 (also known as CHD1L). The cancer-relevant genome reorganization induced by PARP activation is critically dependent on ALC1 activity. Genetic data have revealed that disruption of this ALC1 activity greatly potentiates PARP inhibitors and produces synthetic lethality in BRCA gene mutations. EIS-12656 was developed by exploiting Eisbach’s ALLOS drug discovery platform that recapitulates the selective, unique, and physiological activation mechanism of its target enzymes in the laboratory. Preclinical data showed that EIS-12656 disrupted cancer cell growth by interfering with the DNA damage and repair (DDR) mechanisms of cancer cells while exhibiting a markedly superior toxicity profile in comparison with currently available therapies targeting DDR pathways. With its first-in-kind, allosteric inhibitory mechanism and superior toxicity profile, EIS-12656 may enable novel monotherapy applications and powerful combination therapies.

 

About Eisbach

Eisbach is a pioneering, clinical-stage biotech company focused on precision oncology, aiming to disrupt tumor growth by targeting genetic vulnerabilities. The company develops allosteric drugs that selectively disrupt molecular mechanisms, also known as molecular machines, which are vital for tumor genome reorganization. Eisbach combines the genetic vulnerabilities present in defined tumors (synthetic lethality) with its proprietary drug discovery platform, ALLOS, which targets the unique molecular vulnerability of its drug targets, to create first-in-class therapies with fewer side effects. The company’s pipeline includes several small molecule candidates targeting chromatin reorganization that enable potent combination therapies and suppress resistance mechanisms in cancer treatment. For more information, visit www.eisbach.bio and follow us on LinkedIn.

 

About Cancer Focus Fund

The Cancer Focus Fund LP is a unique investment fund established in collaboration with The University of Texas MD Anderson Cancer Center (MD Anserson). The fund provides investment support to advance promising cancer therapies that are close to being tested in humans or are in early clinical development, as well as the clinical trial expertise and infrastructure of MD Anderson and strategic partners Ochsner Health System Precision Cancer Therapies Program New Orleans and the LSU Feist Weiller Cancer Center Shreveport. The Fund’s objective is to leverage this unique combination to provide investors with superior risk-adjusted returns. In collaboration with partner MD Anderson, the Cancer Focus Fund provides both capital and translational research expertise with the goal of accelerating the development of novel cancer therapies that result in better outcomes for patients while generating returns for investors.

 

Disclosures

The University of Texas MD Anderson Cancer Center’s relationship with Cancer Focus Fund, and all research conducted at MD Anderson related to Cancer Focus Fund, has been identified as an institutional financial conflict of interest by MD Anderson’s Institutional Conflict of Interest Committee and therefore is managed under an Institutional Conflict of Interest Management and Monitoring Plan.

 

Forward-Looking Statement

This press release contains forward-looking statements that involve risks and uncertainties, including those related to the clinical development of EIS-12656 and other potential therapies. Actual results may differ materially from those projected in these forward-looking statements. Factors that could cause actual results to differ materially include, but are not limited to, the progress of clinical trials, regulatory approvals, market demand for new therapies, and competitive dynamics in the biotechnology sector.

 

Contacts

 

Eisbach Bio GmbH

Corporate:

Adrian Schomburg, CEO

mediarelations@eisbach.bio

 

Media:

Jonathan Iorio

+49 89 2153 79013

info@eisbach.bio

 

Cancer Focus Fund

Corporate:

Ross Barrett

Managing Partner

ross@cancerfocusfund.com

 

Media:

Barbara Lindheim

BLL Partners for Cancer Focus Fund

blindheim@bllbiopartners.com

+1 917 355-9234

 

Munich, 26.04.2023:

Eisbach Bio GmbH, a biotechnology company targeting the molecular machines that drive human disease, today announced the start of a Phase 1, first-in-human clinical trial for EIS-10700, a small molecule that targets the RNA helicase of SARS-CoV-2. Eisbach Bio is developing a COVID-19 antiviral as part of the EisCor2 project supported by the German Federal Ministry of Research (BMBF).

The trial is designed to evaluate the safety, tolerability, and pharmacokinetics of their proprietary helicase inhibitor in healthy volunteers. Emerging from Eisbach’s drug discovery platform, EIS-10700 is a novel, SARS-CoV-2-directed small molecule helicase inhibitor that has been developed to suppress viral replication through a mechanism that is conserved across all known COVID-19 variants, thus resistant to potential mutations.

The drug candidate has shown promising results in preclinical studies. The company is now moving forward with clinical trials to further evaluate its safety and tolerability.

“We are excited to announce the initiation of Phase 1 clinical trials for EIS-10700, our first-in-class SARS-CoV-2 helicase inhibitor,” said Dr. Adrian Schomburg, CEO of Eisbach Bio GmbH. “This is an important milestone in the development of our drug, and we look forward to advancing it through clinical trials. We aim to deliver a sustainable medicine to globally reduce COVID-19 hospitalizations and deaths.” The Phase 1 trial will be conducted in collaboration with Nusivan GmbH in Germany and receives support from the German Ministry for Education and Research (BMBF) in the context of the funded EisCor2 project. Eisbach Bio GmbH expects to complete the trial in the coming months and to advance the drug into later-stage clinical trials to test its antiviral efficacy.

About Eisbach Bio GmbH

Eisbach develops novel drugs targeting helicase enzymes, including molecular machines that are essential to tumors with defined genetic vulnerabilities in the context of DNA damage and repair (DDR). Its proprietary helicase platform and discovery engine ALLOS creates targeted therapies that exploit disease-relevant vulnerabilities. By shutting off the machines’ engines using allosteric inhibitors, Eisbach’s impactful medicines prevent the reorganization and evolution of cancer genomes. Founded in 2019, Eisbach is privately held and backed by international investors. For more information, please visit www.eisbach.bio.

More information:

Eisbach Bio GmbH:

www.eisbach.bio

Email: info@eisbach.bio

A nucleic acid chemistry cluster to shape Germany’s R&D future – Eisbach member of the winning C-NATM cluster

 

Munich, 08.08.2022: The cluster C-NATM has emerged as one of the 7 winners in the Clusters4Future competition funded by the German Federal Ministry of Education and Research (BMBF). Eisbach Bio GmbH will contribute its proprietary R&D expertise to the network and develop novel nucleic acid-based therapies for oncology.

The C-NATM network led by Prof. Dr. Thomas Carell and Prof. Dr. Stefan Engelhardt aims to develop new drugs and next generation vaccines based on nucleic acids to cure currently untreatable diseases. Recent discoveries in the field of mRNA vaccines, but also in the field of chemical biology, epigenetics and nucleic acid therapies, now give hope that nucleic acids and related molecules have therapeutic potential as new “weapons” in the anti-viral, anti-cancer and immune modulation field. The cluster includes leading academic and industrial partners. Together, they will develop highly innovative therapeutics in the field of nucleic acid chemistry. Alongside with Roche, Eisbach is committed to support the network over a period of at least 3 years.

Eisbach Bio GmbH’s expertise in drug discovery and development to address nucleic acid-modifying molecular machines for antitumor therapy makes the company an ideal industrial partner for the ambitious project at the interface of chemistry and medicine.

 

About Eisbach Bio GmbH

Eisbach Bio GmbH is a LMU spin off established in January 2019 on the Großhadern-Martinsried campus. Eisbach exploits the innovative therapeutic concept of synthetic lethality in tumor cells and develops small molecule inhibitors for the personalized therapy of cancer in genetically defined patient groups, including for indications with no therapeutic options. Cancer genomics has revealed tumor-specific genes that cancer cells critically depend on for survival. By targeting these molecular vulnerabilities, Eisbach’s inhibitors hit the Achilles heel of tumors, effectively eliminating cancer cells with minimal side effects, while healthy cells remain largely unharmed. Eisbach has developed a proprietary screening and development platform that specifically identifies allosteric inhibitors of these tumor-essential molecular machines, generating efficacious drugs with limited toxicity.

 

About the BMBF’s Future Clusters Initiative:

The German federal Clusters4Future initiative seeks to bring innovations to market. To ensure that Germany remains in the top group of innovation leaders, the BMBF launched an ambitious program to establish several regional R&D clusters that catalyze the existing research cooperation between leading academic institutions and industry.

The fourteen future clusters in total are Germany’s innovation networks of the future. Their aim is to find suitable solutions for the major challenges of our time. The topics are as diverse as the winners’ concepts: neuromorphic hardware for autonomous systems, personalized cell and gene therapy processes, sustainable marine research, quantum technology, new approaches to drug discovery and development, as well as hydrogen fuel technologies. To this end, universities, research institutions, companies, social and other relevant players in the regions have joined forces, sharing exclusive knowledge with each other and pooling their expertise into joint R&D activities.

Eisbach Bio and MD Anderson announce strategic collaboration to develop medicines targeting epigenetic machinery in oncology

MUNICH and HOUSTONEisbach Bio GmbH and The University of Texas MD Anderson Cancer Centertoday announced a strategic research collaboration to jointly discover and develop precision oncology drugs that target synthetic lethal engines key to tumor genome evolution.

The agreement aligns the drug discovery and development expertise of MD Anderson’s Therapeutics Discovery division with the innovative discovery platform and allosteric assay technology of Eisbach to generate medicines that selectively disrupt genome replication and DNA repair in cancers harboring defined genetic alterations.

“Modern genomics has revealed synthetic lethal targets in certain cancers with tumor suppressor gene mutations, and Eisbach has developed tools to pinpoint precisely where these targets are vulnerable at the molecular level,” said Adrian Schomburg, Ph.D., Chief Executive Officer of Eisbach. “We are excited to collaborate with MD Anderson to develop innovative targeted therapies that exploit these unique vulnerabilities.”

Synthetic lethality is a phenomenon in which cancer cells with mutations in certain pathways are hypersensitive to drugs targeting related pathways. Notably, defects in certain DNA damage repair pathways – common to many cancer types – render cancer cells dependent on processes that reorganize the cancer genome.

“Cancers harboring mutations in tumor suppressor genes have been notoriously difficult to treat in the past,” said Timothy A. Yap, M.B.B.S., Ph.D., Associate Professor of Investigational Cancer Therapeutics and Medical Director of the Institute for Applied Cancer Science (IACS) at MD Anderson. “However, growing clinical evidence with PARP inhibitors demonstrates that targeting synthetic lethality is a promising strategy in certain cancer types, and we look forward to continued progress in this space.”

Eisbach and MD Anderson will leverage their complementary expertise to jointly identify targets and develop small-molecule therapies that can shut off specific epigenetic processes, thereby disrupting genome control selectively in tumor cells while sparing normal tissues. With its proprietary assay platform, Eisbach is uniquely capable of identifying and targeting molecular vulnerabilities in this machinery through allosteric mechanisms.

“Our platform identifies the unique activation mechanisms of molecular machines essential for cancer cell growth,” said Andreas Ladurner, Ph.D., Chief Scientific Officer at Eisbach. “With this insight, we are able to develop targeted drugs that selectively interfere with the ignition of the engines that tumor cells have come to rely upon. These drugs are safe and selective by design.”

Eisbach will collaborate with the team at IACS, a drug discovery engine focused on developing novel small-molecule therapeutics. IACS is a core component of MD Anderson’s Therapeutics Discovery division, an integrated team of researchers, physicians and drug development experts working to advance impactful new therapies.

“Our Therapeutics Discovery team is committed to developing the next generation of cancer treatments that address significant unmet needs in oncology,” said Philip Jones, Ph.D., Vice President of Therapeutics Discovery and Head of IACS at MD Anderson. “By focusing on epigenetic machinery in our collaboration with Eisbach, we are hoping to advance additional much-needed therapeutic options that can improve patients’ lives.”

Under the terms of the agreement, Eisbach and MD Anderson will jointly determine the appropriate pathway for future development and possible commercialization on any therapies that show promise in laboratory studies.

About Eisbach Bio GmbH

Eisbach Bio develops novel drugs that disrupt molecular machines essential to tumors with defined genetic vulnerabilities in the context of DNA damage and repair (DDR) pathways. Its proprietary platform creates targeted therapies that exploit disease-relevant vulnerabilities. By shutting off the machine’s engine using allosteric inhibitors, their impactful medicines prevent thereorganization and evolution of cancer genomes. Founded in 2019, Eisbach is privately held and backed by international investors.

 

About MD Anderson

The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world’s most respected centers focused on cancer patient care, research, education and prevention. The institution’s sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 51 comprehensive cancer centers designated by the National CancerInstitute (NCI). MD Anderson is No. 1 for cancer in U.S. News & World Report’s “Best Hospitals” rankings. It has been named one of the nation’s top two hospitals for cancer since the rankings began in 1990. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).

 

More information:

Eisbach Bio GmbH:

www.eisbach.bio

Email: info@eisbach.bio

 

The University of Texas M. D. Anderson Cancer Center

www.mdanderson.org/newsroom

Email: publicrelations@mdanderson.org

 

Eisbach Bio receives €6.7M grant from the Bavarian Government for the development of targeted SARS-CoV-2 antivirals

MUNICH, Germany, October 29, 2021 – Eisbach Bio, a biotechnology company targeting the molecular machines that drive human disease, announces financial support from the Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi) for the preclinical and clinical development of a proprietary SARS-CoV-2 helicase inhibitor and its backups. The funding of EUR 6.7 million will support the development of the Company’s COVID-19 therapeutics and maintain the competitiveness of the biotech scene in Bavaria as part of the BayTherapie 2020 program.

Eisbach aims to bring a safe, sustainable and targeted antiviral drug with specific activity against the SARS-CoV-2 virus into the clinic to lower disease progression and help end the pandemic globally. Using its molecular machine expertise, the Company developed EIS4363, a small molecule inhibitor of the SARS-CoV-2 helicase enzyme Nsp13, which is critical for viral replication and is the most conserved non-structural protein within the extended coronavirus family. The goal of this project is to further develop the chemical structure of the preclinical candidate EIS4363 and to further increase the efficacy in animal models. Additional research will be directed toward developing a highly effective, oral combination therapy with drugs targeting the RNA-dependent RNA polymerase (RdRP), such as molnupiravir.

Eisbach’s CEO, Dr. Adrian Schomburg, commented: “Our team is grateful to receive state support for the development of our drug candidates. The biotech scene in Bavaria and beyond will benefit from this project. Our research progress illustrates how Bavarian companies joined the fight against COVID-19, taking a leading role in driving innovation and identifying therapeutic solutions.”

Prof. Andreas Ladurner, Eisbach’s CSO, added: “We are determined to deliver a sustainable drug with a good safety profile. The funded BayTherapie2020 program will allow us to allocate more resources to the research and development of EIS4363, greatly increasing our chances of developing a much-needed novel antiviral for the global community.”

The financial support adds to the Company’s government-funded grants for the development of its novel targeted antivirals. Eisbach is rapidly progressing its IND-enabling work and expects to initiate Phase I clinical trials for its nominated COVID-19 asset in Q2, 2022.

  

About Eisbach Bio GmbH:

Eisbach develops novel drugs that disrupt molecular machines essential to tumors with defined genetic vulnerabilities in the context of DNA damage and repair (DDR). Its proprietary allosteric platform creates targeted therapies that exploit disease-relevant vulnerabilities. By shutting off the machine’s engine using allosteric inhibitors, Eisbach’s medicines are designed to prevent the reorganization and evolution of cancer genomes. In early 2020, Eisbach joined the global effort to fight the COVID-19 pandemic by exploiting its allosteric platform for the identification of small molecule antivirals targeting related molecular machines and engines in SARS-CoV-2. Founded in 2019, Eisbach is privately held and backed by international investors. For more information, please visit www.eisbach.bio.

 

More information:

Eisbach Bio GmbH

Email: info@eisbach.bio

https://www.eisbach.bio

Press Release

Collaboration Eisbach Bio GmbH & Technische Universität Kaiserslautern

MUNICH, Germany, September 1, 2021 – Eisbach Bio GmbH and the team of Prof. Dr.-Ing. Naim Bajcinca from the Technische Universität Kaiserlautern (TUK) announce a collaboration where they will use deep learning to track and trace arising mutations in the genome of SARS-CoV-2 and develop sustainable small molecule inhibitors that will target the virus for the long-term.

The project titled AI-based Mutation Prediction and Relevant Protein Inhibitor Development in SARS-CoV-2 (AIMPID) is focused on predicting mutations in the SARS-CoV-2 genome and developing small inhibitor molecules which target the virulent protein products of predicted mutations to block their activities. Being an RNA virus, SARS-CoV-2 is prone to mutations in its genome. These mutations will likely render current vaccines and drugs less effective over time. The tracing of mutation patterns in the viral genome will allow for the identification of the least mutable regions. This knowledge will help the collaborating teams to design more enduring, sustainable inhibitor molecules, which will help controlling the global spread of pandemic. The main tasks of the project include the prediction of the mutation rate, of the specific mutated residues among all viral proteins and the development of small inhibitor molecules against one or more specific target proteins translated from the virus’ mutated RNA sequences. One objective of the collaboration is to generate a small molecule inhibitor of a critical SARS-CoV-2 protein that has the potential to inhibit current and future variants of the SARS-CoV-2 virus.

The project is partially financed by the ZIM Programme of the Federal Ministry for Economic Affairs and Energy (www.zim.de). It is a collaboration between Eisbach’s R&D department and the Chair of Mechatronics in Mechanical and Automotive Engineering of the TUK.

The development of antiviral drugs based on deep learning shall complete Eisbach’s other COVID-19 assets and will run in parallel to already developed small molecule inhibitors.

More information:

Eisbach Bio

Email: info@eisbach.bio

www.eisbach.bio

Technische Universität Kaiserslautern

Chair of Mechatronics in Mechanical and Automotive Engineering

Email: ahtisham.abbasi@mv.uni-kl.de

www.mv.uni-kl.de/mec

Press Release

 

Eisbach Bio receives EUR 8 million government grant to progress COVID-19 antiviral through Phase I/II clinical development

MUNICH, Germany, July 7, 2021 – Eisbach Bio, a biotechnology company targeting the molecular machines that drive human disease, today announced additional financial support from the German Ministry for Education and Research (BMBF) for the clinical development of its first-in-class SARS-CoV-2 helicase inhibitor. The total funding of EUR 8 million will support the clinical development of the Company’s novel COVID-19 therapeutic following the recent completion of its preclinical development.

Eisbach is using its allosteric inhibitor platform to develop selective drugs for the inhibition of complex molecular machines involved in serious diseases. In cancer, it has identified synthetic-lethal and oncogenic helicases as targets and developed small-molecule inhibitors targeting specific chromatin remodeling enzymes. Using its helicase expertise, the Company also developed an inhibitor of the SARS-CoV-2 helicase Nsp13, an RNA helicase critical for viral replication and the most conserved non-structural protein within the coronavirus family.

Eisbach’s CEO, Dr. Adrian Schomburg, commented: “We are very thankful to receive BMBF support for the clinical validation of our drug candidate, which allows for convenient oral administration. As the tablets can be easily manufactured and shipped, our drug candidate not only offers broad potential to alleviate disease symptoms, but also to globally reduce COVID-19 hospitalizations and deaths.”

Prof. Andreas Ladurner, Eisbach’s CSO, added: “Our drug blocks viral replication through a novel, targeted mechanism that is fully conserved across all known virus variants. We are determined to deliver a sustainable drug with a good safety profile that should allow treatment of anyone testing positive for SARS-CoV-2, especially high-risk patients.”

The antiviral adds to the Company’s original oncology pipeline, consisting of first-in-kind inhibitors for synthetic-le thal cancer targets. Eisbach is rapidly progressing its IND-enabling work and expects to initiate Phase I clinical trials for its COVID-19 asset in Q1, 2022.

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About Eisbach Bio GmbH

Eisbach develops novel drugs that disrupt molecular machines essential to tumors with defined genetic vulnerabilities in the context of DNA damage and repair (DDR). Its proprietary platform creates targeted therapies that exploit disease-relevant vulnerabilities. By shutting off the machine’s engine using allosteric inhibitors, Eisbach’s medicines are designed to prevent the reorganization and evolution of cancer genomes. Founded in 2019, Eisbach is privately held and backed by international investors. For more information, please visit www.eisbach.bio.

More information:

Eisbach Bio

Email: info@eisbach.bio

https://www.eisbach.bio

 

Media Inquiries:

akampion

Dr. Ludger Wess / Ines-Regina Buth

Managing Partners

info@akampion.com

Tel. +49 40 88 16 59 64 /

Tel. +49 30 23 63 27 68

 

Link to BMBF press release

MUNICH, Germany. April 16th, 2021 – Eisbach Bio, a biotechnology company targeting the molecular machines that drive human disease today announced additional financial support from the German Ministry for Education and Research (BMBF) for the clinical development of its first-in-class SARS-CoV-2 helicase inhibitor. Leveraging Eisbach’s proprietary drug discovery platform, the company has concluded preclinical development of its candidate molecule. Eisbach and 7 additional German companies were awarded BMBF funding to support the clinical development of novel COVID-19 therapeutics, as announced by the Federal Minister for Education and Research, Ms. Anja Karliczek.

Eisbach’s CEO, Dr. Adrian Schomburg, commented: “We are very thankful to receive BMBF support to clinically validate our once-a-day remedy. The tablets are easy to manufacture and distribute, offering the potential to alleviate disease symptoms and globally reduce COVID-19 hospitalizations and deaths.” Prof. Andreas Ladurner, Eisbach’s CSO, added: “Our drug blocks viral replication through a novel, targeted mechanism that is fully conserved across all known virus variants. We are determined to deliver a sustainable medicine with a safety profile that should allow anybody testing positive for SARS-CoV-2 to take this medicine.”

The antiviral adds to the company’s strong oncology pipeline, consisting of first-in-kind inhibitors for two synthetic-lethal cancer targets. Eisbach is rapidly progressing its IND-enabling work and expects to initiate Phase I clinical trials for its COVID-19 asset in Q3 2021.

About Eisbach Bio GmbH:

Eisbach develops novel drugs that disrupt molecular machines essential to tumors with defined genetic vulnerabilities in the context of DNA damage and repair (DDR). Its proprietary platform creates targeted therapies that exploit disease-relevant vulnerabilities. By shutting off the machine’s engine using allosteric inhibitors, their impactful medicines prevent the reorganization and evolution of cancer genomes. Founded in 2019, Eisbach is privately held and backed by  international investors. For more information, please visit www.eisbach.bio.

Link to BMBF press release

Collaboration Core Facility Animal Models & Eisbach Bio GmbH

The Core Facility Animal Models (CAM) of the Biomedical Center of the LMU announces a collaboration with drug discovery start-up Eisbach Bio GmbH to test SARS-CoV-2 antivirals.

Eisbach has developed small molecule inhibitors which target disease-relevant and novel mechanisms in SARS-CoV-2 for the treatment of COVID-19 and is now concluding late-stage pre-clinical development together with the CAM. The CAM is conducting animal studies to evaluate the new compounds with respect to their drug metabolism as well as tolerability. The inhibitors which directly shut off viral replication of SARS-CoV-2 could be given so far at high doses with no detectable toxicity nor side effects. Clinical trials are expected to start this summer.

The Core Facility Animal Models (CAM) at the Biomedical Center is a scientific unit of the LMU Munich providing scientists a platform to conduct animal experimentation in accordance with the legal requirements of the European and national (German) law. Core responsibility of the CAM is to care for all on-site animals subject to animal research experimentation. In addition, the CAM team supports scientists in the planning and realization of experiments as well as in providing expert advice and counseling toward legal authorities and government offices.

Eisbach Bio GmbH is a LMU spin off established in January 2019 on the Großhadern-Martinsried campus. The start-up develops novel drugs targeting essential motor proteins through allosteric mechanisms. Their technology allows to develop impactful medicines in oncology, where these machines use their engine’s power to reorganize the human genome, especially in the context of DNA damage and repair. Inhibitors targeting these machines hold great promise in treating cancer. In February 2020, Eisbach joined the worldwide efforts to combat the Coronavirus pandemic and is on-track to develop the first effective, targeted, enduring and sustainable antiviral COVID-19 therapy. The project received funding from the BMBF as part of their call to tackle the pandemic in spring 2020.